In silico trials with v-Patients by Virtonomy
End-to-end digital twin solution
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Create digital twins based on clinical data of thousands of humans & animals
Perform data-driven in silico clinical trials to optimize your medical device design
Gain valuable insights with a statistical population analysis and simulations
What are the main features of v-Patients?
Virtual Patients Base Product
Create your own virtual patient population using our extensive database of humans and animals. Detailed criteria allow for a proper selection of the target population based on anatomical variation, demographic diversity and pathological conditions. Virtual anatomy studies, static fitting of the implant and interactive measurements can be performed using our web-based 3D viewer.
Evaluate the design changes in the virtual room together with your colleagues, clinical advisors or external engineers with our multi-user environment using your computer, tablet or virtual reality headset.
Main features:
- Virtual patient cohort creation
- Virtual implantations and interactive analysis
- Anatomy studies of 3D models
- Collaborative analysis
Statistical Analysis
Your virtual patient cohort is linked to a statistical population analysis, forming a library of body variations to allow you evaluate the proper target sub-population cohort, define inclusion/exclusion criteria, assess worst-case scenarios and more. Determine the ideal fit of your device and how to adjust your design to treat the maximum number of patients.
Also create average models of certain groups of your population cohort using our Statistical Shape Model (SSM) approach. Create synthetic cohorts based on statistical models and use them with other v-Patients modules. Using this module will increase evaluation confidence by recruiting patients for your in silico trials who specifically match your target group.
Main features:
- Statistical population analysis
- Statistical shape models
Simulation & Optimization
Simulate your implant or product family in the entire virtual target population to investigate how these body variations may affect the performance and safety of your device. In addition, identify the potential for design optimization and material selection by conducting parameter analyses.
We offer a device and use case tailored customized simulation environment based on your use case and product phase. Get access to an easy to use, intuitive solution where no expert simulation knowledge is needed.
Main features:
- Simulated virtual implantation
- Data-driven optimization
- Device and use-case tailored environment for in silico trials
Design History & Regulatory Approval
Compared to conventional in vivo and in vitro testing, in silico trials of implants are more time and cost efficient. We provide digital evidence of your anatomy, statistical and simulation results to support your technical documentation with FDA-compliant reporting (FDA 1807 & ASME V&V40).
This significantly shortens development cycles and the pre-clinical testing efforts for technical documentation.
Main features:
- Regulatory-compliant reports
- Tracking of device design changes
OUR DATABASE
We develop our digital twins from real imaging data.
We are constantly expanding our database of imaging scans and 3D anatomical models of both humans and animals.
Our library consists at the moment of mostly cardiac models, but we are expanding to orthopaedics as well.
Choose different parameters to create your digital twin:
Pathology:
- Heart failure
- Tricuspid valve insufficiency
- Aortic stenosis
- Mitral valve insufficiency
- and more…
Location or ethnicity:
- Europe
- North America
- Asia
- and more…
Age group:
- Pediatric patients
- Adult patients
- Geriatric patients
Animal breeds:
- Sheep (Milksheep, Île-de-France, Swifter)
- Pig (Domestic, LeWe-Minipig)
- Calf (Jersey)
- and more…
The data and the analysis that Virtonomy has provided during our partnership are key tools for strengthening and expanding our knowledge basis of the anatomical boundary conditions.
Davide Mogentale, R&D Manager
Medira GmbH
v-Patients: From clinical data to digital evidence
Exemplary use case of a transcatheter valve replacement
v-Patients Base
Analyse the right heart and transfemoral access
route for the implantation of a transcatheter valve
application
Automatic pipeline from data to model using in-house developed AI & Computer Vision
v-Patients Statistics
Perform statistical analysis of 50+ right heart patients to define inclusion/exclusion and sizing criteria, assess worst case scenarios, and more
Huge database in the cardiovascular field allows us to perform high diversity analysis
v-Patients Simulation
Perform solid, fluid and electrophysiology
simulations to predict device-tissue-blood
interaction
Developing the most advanced browser-based simulation framework for healthcare applications
v-Patients Reg. Reporting
Create regulatory-compliant digital evidence
of your results to support your technical
documentation
Automatic regulators-compliant report revolutionizing the regulatory submission process
Also available in VR for an immersive experience!
Use the virtual reality mode and view anatomy and different anatomical measurements, investigate device fit through a virtual device implantation and perform simulations.
Virtual implantation brings enormous benefits to speeding up product development in a data driven manner and complementing the animal studies. Now VR technology just takes this to the next new level, and it is exciting to develop an artificial organ in the metaverse!
Oliver Chu, Principal Engineer
Scandinavian RealHeart
Ready to cut your device development time and costs?
We are passionate about helping medical device developers shorten their time-to-market and develop new products faster.